In force Publication date 13 Apr 15
The use of Cytochrome P450 inhibitors in sport. A new generation of doping masking agents
Project Title: The use of Cytochrome P450 inhibitors in sport. A new generation of doping masking agents
Researchers: M. Mazzarino, F. Botrè, X. de la Torre, A.B. Cadwallader, F. Donati
Institution: Federazione Medico Sportiva, Italy
Year accepted: 2010
Summary: This project is designed to provide information on the role that inhibitors of the most abundant CYP450 enzymes may have in doping scenarios. Specifically, the metabolic profile of selected banned compounds, with special emphasis on threshold compounds and to compounds that are excreted in urine mainly as CYP450 metabolites will be assessed individually and in the presence of selected CYP inhibition agents in vitro, in order to establish if the co-administration of CYP inhibitors with doping agents could be used by athletes as masking strategy.
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