In force Publication date 04 Mar 19

Factors affecting pharmacokinetics of inhaled salbutamol in athletes: Application of 4O sulfate metabolite analysis to improve predictive value of AAFs

Project description

Project Title: Factors affecting pharmacokinetics of inhaled salbutamol in athletes: Application of 4O sulfate metabolite analysis to improve predictive value of AAFs

Researchers: Dr. M. Hostrup (University of Copenhagen, Denmark), Dr G. Jacobson (University of Tasmania, Australia), Dr. Y. Dehnes (WADA Doping Control Laboratory, Norway)

Year accepted: 2018

Summary: This project will provide a comprehensive investigation into the factors that affect the intra- and inter-individual pharmacokinetics of salbutamol in female and male athletes. The primary objective is to model the peak urine excretion rate and peak urine concentrations of unchanged salbutamol and its major 4'O sulfate metabolite after permitted inhalation and prohibited oral ingestion to possibly improve the predictive value and accuracy of the decision limit for salbutamol.

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