In force Publication date 24 Jul 18

Ultra-Sensitive Mass Spectrometric Detection of a rEPO Specific O-glycopeptide as an Unambiguous Proof of Doping—Follow-up (GOpep2)

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Project Title: Ultra-Sensitive Mass Spectrometric Detection of a rEPO Specific O-glycopeptide as an Unambiguous Proof of Doping—Follow-up (GOpep2)

Researcher: Dr. J. Pascual, Dr. J. Segura

Institution: Fundacio IMIM (FIMIM), Spain

Year accepted: 2017

Summary: The hypothesis of this project is that MS sensitivity has reached a status in which EPO glycopeptides, particularly O-glycopeptides as they present lower heterogeneity, are detectable in urine or blood samples. Using a proper combination of specific peptide immunopurification with other desalting techniques, matrix effects can be avoided and the required sensitivity for the EPO O-glycopeptide containing the non-human tag (Neu5Gc) reached.

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