Metabolism of steroids via humanized livers in mice

Project Title: Metabolism of steroids via humanized livers in mice

Researchers: F.T. Delbeke, G. Lerouxm Roels, P. Van Eenoo

Institution: Doping Control Laboratory, Ghent, Belgium

Year accepted: 2006

Summary: This study will evaluate an animal model in which mice harbouring a functional human liver will be used for investigation of the metabolism of steroids. In contrast to, in-vitro models using single cells or cell cultures, this animal uses a functional human liver and resembles administration studies better than any other model available so far.