In force Publication date 17 Feb 15
Masking strategies in sport doping: Modulation of phase II metabolism
Project Title: Masking strategies in sport doping: Modulation of phase II metabolism
Researchers: Dr. M. Mazzarino, Dr. F. Botre, Dr. X. de la Torre
Institutions: Federazione Medico Sportiva Italiana, Italy
Year approved: 2012
Summary: In this project we plan to follow an analogous approach to preliminarily investigate whether the co-administration of doping agents with other xenobiotics that are substrate of the UGTs could be used by athletes as a strategy to evade anti-doping testing. Specifically, the in vitro phase II metabolic profile of selected banned compounds, with especially emphasis on threshold substances (i.e 19-norandrosterone, morphine and tetrahydrocannabinol) will be assessed individually and in the presence of selected medicaments commonly used by athletes (non steroidal anti-inflammatory agents, antifungal agents and benzodiazepines).
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