In force Publication date 13 Apr 15
Implementation of HPLC/orbitrap mass spectrometry as a general screening method for doping control
Project Title: Implementation of HPLC/orbitrap mass spectrometry as a general screening method for doping control
Researchers: G. Rodchenkov, E. Virus, M. Dikunets, E. Semenistay, T. Raduschina, T. Sobolevsky
Institution: Moscow Antidoping Centre, Department of Doping Control, Moscow, Russia
Year accepted: 2009
Summary: A full description and validation as a general screening method based on SPE and HPLC/orbitrap mass spectrometry with different ionization techniques for doping agents, including anabolic steroids, beta2-adrenergic agonists, SARMs, agents with antiestrogenic activity, diuretics, stimulants, beta-blockers, and cannabinoids. Validation of the method will consist of investigation of specificity, analytical recovery, limit of detection, and repeatability. Finally, a comparison of the HPLC/orbitrap mass spectrometry and HPLC/MS/MS methods for the qualitative screening of prohibited substances in urine will be performed.
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