In force Publication date 23 Feb 15
High sensitive detection of genetically and pharmacological manipulations of the myostatin signal transduction pathway by multiplex immuno pcr fingerprint analysis
Resource description
Project Title: High sensitive detection of genetically and pharmacological manipulations of the myostatin signal transduction pathway by multiplex immuno PCR fingerprint analysis
Researchers: P. Diel, T. Schiffer (German Sports University, Cologne, Germany), M. Adler (Chimera Biotech GmbH, Germany)
Year accepted: 2005
Summary: The presented project aims to establish Real time iPCR as a new tool for highly sensitive detection of members of the myostatin signal transduction pathway in skeletal muscle, blood, oral mucosa, and urine. As targets we will choose myostatin itself, myostatin propeptide, follistatins, the follistatin related gene (FLRG), the activin receptors ActRIIA and ActRIIB, the family of activin receptor –interacting proteins (APRIPs) and gasp-1. The technique of iPCR will allow to analyse these parameters simultaneously using multiplex real time PCR.