In force Publication date 01 Jan 11

Development of reliable blood tests for the detection of gene doping after intramuscular injection of recombinant adeno-associated viral vectors

Resource description

Project Title: Development of reliable blood tests for the detection of gene doping after intramuscular injection of recombinant adeno-associated viral vectors

Researchers: Dr. Snyder (University of Florida, USA), Dr. Mouillier (University of Nantes, France), Dr. Simon (Johannes Gutenberg-University, Germany)

Year approved: 2011

Summary:

  • Aim 1: Evaluate a combined assay format that is based on real-time PCR and ITC readout with a nested PCR pre-step to improve sensitivity.
  • Aim 2: Assay analytical validation for specificity, sensitivity, and ruggedness (multiple labs, multiple operators, repeats and replicates) and preliminary pre-clinical performance validation.

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