In force Publication date 01 Jan 11
Development of reliable blood tests for the detection of gene doping after intramuscular injection of recombinant adeno-associated viral vectors
Resource description
Project Title: Development of reliable blood tests for the detection of gene doping after intramuscular injection of recombinant adeno-associated viral vectors
Researchers: Dr. Snyder (University of Florida, USA), Dr. Mouillier (University of Nantes, France), Dr. Simon (Johannes Gutenberg-University, Germany)
Year approved: 2011
Summary:
- Aim 1: Evaluate a combined assay format that is based on real-time PCR and ITC readout with a nested PCR pre-step to improve sensitivity.
- Aim 2: Assay analytical validation for specificity, sensitivity, and ruggedness (multiple labs, multiple operators, repeats and replicates) and preliminary pre-clinical performance validation.