In force Publication date 18 Feb 15
Detection and identification of plasma volume expanders based on polysaccharide structures in human urine combined with the analysis of the diuretic mannitol
Project Title: Detection and identification of plasma volume expanders based on polysaccharide structures in human urine combined with the analysis of the diuretic mannitol
Researchers: W. Schänzer, M. Thevis
Institution: Deutsche Sporthochschule Köln, Institut für Biochemie, Köln, Germany
Year accepted: 2002
Summary: A comprehensive method of sugar analysis which should include the plasma volume expanders HES (already published) and dextran and additionally the diuretic mannitol should extend and improve the possibilities of analysis in doping control urine samples. The scandals of the world championships in Lahti showed the necessity of the detection of this class of substances and, due to the close chemical similarity of some plasma volume expanders and mannitol, methods for the determination of abuse of these compounds should be established. Therefore, the development of sensitive and specific identification procedures are planned based on chemical analysis of excretion study urine specimen, reference compounds, consideration of earlier metabolism studies and routine analysis of doping control samples.
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