Can the application of the anti-malaria drug proguanil lead to an adverse analytical finding for the diuretic agent chlorazanil?

Project Title: Can the application of the anti-malaria drug proguanil lead to an adverse analytical finding for the diuretic agent chlorazanil?

Researcher: Prof. W. Schänzer

Institutions: Center for Preventive Doping Research, German Sport University, Germany and Agence Française de Lutte contre le Dopage (AFLD), France

Year accepted: 2014

Summary: The structure of metabolites of the non-prohibited anti-malaria drug proguanil suggests that they can be converted to chlorazanil. To check this hypothesis it should be found out whether chlorazanil is a metabolite of proguanil or whether proguanil metabolites are converted in the urine to chlorazanil by chemical or bacterial influences or whether chlorazanil is a byproduct of the synthesis of proguanil. Furthermore parameters should be identified which allow a discrimination between the application of the non-prohibited proguanil and the prohibited chlorazanil