In force Publication date 13 Apr 15

Beta2-agonists: modes of action and new tools for their detection

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Project Title: Beta2-agonists: modes of action and new tools for their detection

Researchers: R. Candau (Université de Montpellier, France), S. Anderson (Prince Alfred Hospital, Australia), B. Bardy, A. Bonnieu (Université de Montpellier, France), F. Borrani (University of Lausanne, Switzerland), K. Collomp (Université d’Orleans, France), O. Coste (DRDJS Languedoc-Roussillon, France), D. Freyssenet (Université Jean Monet, France), C. Gernigon, PY. Guillaume (Université Montpellier, France)

Year accepted: 2008

Summary: This project, which constitutes a follow-up from a previous work funded by WADA, aims at widening our understanding of the effects of β2-agonists on muscle function, cognitive function and exercise performance. Three main issues will be addressed:

  • Results of two bronchial provocation tests widely used for asthma detection in athletes (mannitol and eucapnic voluntary hyperpnea) will be confronted;
  • Ergogenic and stimulant effects associated with the administration of β2- agonists will be specified;
  • The precise signalling pathways involved in physiological adaptations induced by β2-agonists will be clarified.

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