Androgen/growth factor study in young (AGSY)

Project Title: Androgen/growth factor study in young (AGSY)

Researchers: C. Hagen (Odense University Hospital, Odense, Denmark), E. Haug (The Hormone Laboratory, Aker University Hospital, Trondheimsvien, Norway)

Year accepted: 2002

Summary: The objectives of these studies are:

a) To establish a reference interval for the serum concentration of total-T, free-T, total-E2, free-E2;

b) To evaluate the impact of BMI, fat parameters, chronic disease (gynecomastia, microtestis etc.) and medication on testosterone, free-testosterone and estradiol levels. using probit evaluation;

c) To evaluate a positive role of high, medium, and low testosterone levels on:

• muscle mass, muscle strength, muscle power, and oxygen uptake
• bone mineralization (BMD) and bone metabolism
• cardiovascular risk factors/metabolic syndrome: fat mass, serum lipids, glucose, metabolism, blood pressure
• hematocrit, growth factors
• signs of hypogonadism by medical history as well as clinical signs
• sexual function
• quality of life