Investigation of the Metabolic Profiling of Endogenous Anabolic Androgenic Steroids in the Chinese Population

Code: 25T242D01CW

The present project will conduct an integrated study on Endogenous Anabolic Androgenic Steroids (EAAS) metabolism in the Chinese population. The population distribution of UGT2B17 gene polymorphism, the long-term comparison of EAAS metabolism among individuals with different UGT2B17 gene deletion polymorphisms, and testosterone intervention experiment are the main focuses of this project. Through population studies, long-term research, and interventional trials, the metabolic profile characteristics of testosterone in the Chinese population will be illustrated. The metabolic characteristics of populations having different UGT2B17 genotypes will be highlighted.

Especially focusing on the long-term study data, which can reflect the environmental influence on urine EAAS and provide a data reference for the optimization of biological passports in the future. By correlating blood steroid profiles, urinary steroid profiles, and stable carbon isotope ratio fingerprint features, basic data and case analyses will be provided for EAAS substance detection in the UGT2B17 del/del population. A comprehensive detection strategy for EAAS, including the combined application of BSP, SP and GC/C/IRMS will be discussed in the project. The influencing factors of diet, region, and other factors on EAAS metabolism in the Chinese population will also be studied. ‌Although DBS analysis is not included in this project, the samples will be collected for subsequent investigation.