Mass spectrometric characterization and identification of endogenous and synthetic insulins

Project Title: Mass spectrometric characterization and identification of endogenous and synthetic insulins

Researchers: W. Schänzer, M. Thevis

Institution: German Sport University, Cologne, Germany

Year accepted: 2003

Summary: In order to identify rapid- and long-acting insulins, their mass spectrometric properties after electrospray ionization have to be elucidated. As differences of endogenous and synthetic insulins are limited to exchanges of few amino acids, and one compound is identical with human insulin regarding molecular weight, product ion experiments have to be optimized to efficiently analyze the target compounds in low concentrations in biological fluids.