In force Publication date 21 Jul 15
Detection of circulating anti-Neu5Gc antibodies as a proof of use of recombinant glycoproteins: rEPO and analogues
Project Title: Detection of circulating anti-Neu5Gc antibodies as a proof of use of recombinant glycoproteins: rEPO and analogues
Researchers: Dr. Pascual, Dr. Bolos, Dr. Segura
Institution: Fundacio IMIM, Spain
Year approved: 2011
Summary: The main objectives of the project are:
- Developing a test to quantify antibodies against Neu5Gc circulating in human blood (serum or plasma) based on what has already been described in the literature.
- Test human blood samples from healthy individuals and from patients being treated with rEPO.
- Refine the analytical test in order to increase specificity and minimise background by testing different Neu5Gc containing antigens and approaches (inhibition).
- Validate the test for anti-doping purposes establishing thresholds to ascertain the illegal exposure to recombinant glycoproteins as well as studying the pharmacokinetics of antibody production.
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