In force Publication date 20 Feb 15
Combined screening on diuretics and heavy volatile nitrogen containing doping substances, investigations on the metabolism and synthesis of phase II metabolites
Resource description
Project Title: Combined screening on diuretics and heavy volatile nitrogen containing doping substances, investigations on the metabolism and synthesis of phase II-metabolites
Researchers: W. Schänzer, M. Parr
Institution: German Sport University, Cologne, Germany
Year accepted: 2005
Summary: The project aims at combining the screening methods for diuretics, beta-2-agonists, heavy volatile stimulants and narcotics in one LC-MS/MS method. To avoid problems with the stability of diuretics during the hydrolysis, direct analysis of the excreted metabolites (where applicable as intact conjugates) is mandatory. This is also beneficial because relatively clean extracts are obtained and the time consuming hydrolysis is eliminated.