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Muscle memory after treatment with anabolic substance clenbuterol and resistance training in humans: Myonuclear addition, hypertrophy and myocellular reprogramming
Description du projet
Code: 22C12MH
An emerging concern regarding the misuse of anabolic doping substances in sports is “muscle memory” – as skeletal muscle that has previously been exposed to an anabolic prohibited substance may adapt more readily to retraining. While this phenomenon has been demonstrated in rodents, the underlying mechanisms as well as whether this applies to humans remain unknown. The relevance of studying muscle memory induced by prohibited substances is clear when considering the current anti-doping regulations. One can imagine a scenario where an athlete is banned from competitive events for a few years, but upon return to competitive sport still enjoys an advantage in retraining potential because of anabolic compound-induced muscle memory.
This project will elucidate whether prior treatment of the two commonly misused prohibited anabolic compounds, clenbuterol or testosterone, induces muscle memory and thus improves the hypertrophic response to subsequent resistance training. To this end, two longitudinal randomized placebo-controlled trials will be conducted in healthy volunteers undergoing periods of resistance training. The project will utilize state-of-the-art methodologies to address aspects of myocellular addition, hypertrophy and myocellular reprogramming in muscle biopsies collected during the trials.