Studies of glucocorticoids after intravenous administration: evaluation of washout periods.

Code: 25T01RV

Glucocorticoids (GC) are forbidden in sports competitions when used by injectable, oral or rectal routes. They are allowed by other routes for therapeutic purposes. Since most GCs are marketed in different administration forms, the distinction between routes of administration is needed to ensure safe treatments by allowed routes of administration and to detect the use for doping purposes during competitions. Based on scientific data available, compound-specific reporting levels were established for some GC and washout periods after some administration routes.

There is no data in literature regarding concentrations of GCs in urine after intravenous administration. The objective of the present project will be to perform administration studies with dexamethasone (DEX) and methylprednisolone (MP) using intra-venous (IV) administration, to evaluate the suitability of the reporting levels already defined for DEX and MP to detect IV administration and to define the washout periods after IV administration to avoid fase adverse analytical findings due to treatments close to competitions.