In force

Synthesis of recently reported phase II metabolites for their inclusion in routine doping control analysis

Resource description

Project Title: Synthesis of recently reported phase II metabolites for their inclusion in routine doping control analysis

Researchers: Dr. O. Pozo, Dr. J. Segura, Dr. R. Ventura

Institution: IMIM - Hospital del Mar Medical Research Institute, Spain

Year accepted: 2012

Summary: The goals of this project are:

  • to synthesize at a larger scale several phase II metabolites previously identified as useful for the doping control field (6β-hydroxyandrosterone glucuronide, 6β-hydroxyetiocholanolone glucuronide, epiboldenone sulphate, 17α-methyl-5βandrostane-3α,17β-diol 3α-sulphate, 17β-methyl-5β-androstane-3α,17α-diol 3α-sulphate and 17βmethyl-5α-androstane-3α,17α-diol 3α-sulphate),
  • to fully characterize them by well established techniques (NMR spectroscopy, mass spectrometry),
  • to study their stability and
  • to develop analytical approaches to quantify conjugated metabolites of testosterone (6βhydroxyandrosterone glucuronide, 6β-hydroxyetiocholanolone glucuronide). The synthetized standards will be distributed among WADA accredited laboratories.

Download options

Available in 1 language.