Studies of glucocorticoids after oral administration: evaluation of reporting levels and washout periods

Project Title: Studies of glucocorticoids after oral administration: evaluation of reporting levels and washout periods

Researcher: Rosa Ventura

Institution: Doping Control Research Group, Fundació IMIM, Barcelona, Spain

Year accepted: 2020

Summary: The research will be focused on the following specific objectives:

• To perform excretion studies of DEX, MP and DEF with administration of one single oral dose. For DEX, multiple oral doses will be also studied.
• To measure concentrations in urine of the parent compounds and the main metabolite in case of DEF, to evaluate the reporting levels and washout periods.
• To measure concentrations of the compounds and cortisol in plasma, to evaluate the concordance of the urinary reporting levels and washout periods proposed with plasma concentrations of the active drug and the systemic effect.