Detection of doping with 1-Testosterone

Project Title: Detection of doping with 1-Testosterone

Researcher: M. Wu

Institution: National Research Institute of Sports Medicine, Beijing, China

Year accepted: 2003

Summary: This project will study:

• Firstly, on the main chemical natures with HRMS for element am position, HIR for functional groups in the molecular, LC/MS/MS or GC/MS/MS for chromatographic and mass spectrometric behaviors, GC/C/MC for isotop ratio values
• Secondly, two different excretion studies with 5 volunteers will be carried out respectively, one excretion study will be on the oral administration with 300mg/day and the other on the 150mg/day with ethergel.
• Thirdly, after comparison of analytical results for blank urines and excretion study urines, all the proposed metabolites will be analyzed with the instruments mentioned above. To identify these naturally occurred or endogenously introduced metabolites, GC/C/MS or MS/MS or HRMS should be implemented.
• Fourthly, the validation of this method proposed by this project shall be checked not only in our lab, but in other IOC labs also. Comparison between Laboratories shall be organized randomly and double-blindly in due time.