In force Publication date 15 Jul 15
Application of Metabolomic to Doping Controls-Investigating alternative markers for Testosterone and Growth Hormone abuse using mass Spectrometry and Biostatistics
Project Title: Application of Metabolomic to Doping Controls- Investigating alternative markers for Testosterone and Growth Hormone abuse using mass Spectrometry and Biostatistics
Researchers: Dr. M. Thevis, Dr. A. Thomas
Institution: German Sport University Cologne, Germany
Year approved: 2012
Summary: In order to assess whether –omics strategies such as urine metabolomics can indicate the misuse of drugs relevant in a doping control context, a pilot study was conducted, probing for the potential of this analytical strategy of identifying samples collected during and after applications of anabolic-androgenic steroids. Three scenarios were pursued with controlled administration studies including (1) oral, and (2) transdermal testosterone, where both intra- and interindividual variations of the metabolome were measured. In addition, the metabolome of a reference population of healthy and active individuals was compared to the urinary metabolome of athletes tested positive for the misuse of anabolic-androgenic steroids in routine doping controls (3).
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