Cannabinoid

  1. What is a cannabinoid?
  2. What is a natural cannabinoid?
  3. What is a synthetic cannabinoid?
  4. Why cannabidiol is no longer prohibited?
  5. What is the status of nebulizers?

1. What is a cannabinoid? Up

One of many chemical compounds produced by the cannabis (marijuana) plant. The most notable cannabinoid is delta-9-tetrahydrocannabinol (THC). Other common natural cannabinoids include cannabidiol (CBD) and cannabinol (CBN). In addition to natural cannabinoids, there are also synthetic (man-made) cannabinoids.

2. What is a natural cannabinoid? Up

There are many various compounds found in the cannabis plant,  including THC, the main psychoactive ingredient in the cannabis plant. Others include cannabidiol (CBD). 

3. What is a synthetic cannabinoid? Up

Synthetic cannabinoids were created in laboratories, in some cases to simulate the psychoactive effects of THC, and include synthetic THC (a replica of the natural cannabinoid) as well as other synthetic substances that mimic (hence cannabimimetic) the effects of THC. Synthetic cannabinoids include prohibited recreational and/or black market drugs with psychoactive properties as well as the non-prohibited synthetic CBD.

4. Why cannabidiol is no longer prohibited? Up

Cannabidiol is not a cannabimimetic and has no psychoactive activity. Synthetic cannabidiol will not have THC but cannabidiol extracted from cannabis plants may also contain varying concentrations of THC, which remains a prohibited substance

5. What is the status of nebulizers? Up

Nebulizers are by definition inhalation devices and thus not prohibited as a method. However, the inhalation of salbutamol in doses recommended by the manufacturer is most likely to result in urinary levels of salbutamol exceeding the urinary threshold of 1,000 ng/ml and thus, the use of salbutamol with a nebulizer requires a TUE. However, a TUE for nebulized salbutamol would be granted only in rare situations, such as a severe acute asthma attack treated in an emergency room setting. In otherwise healthy adults, the use of metered dose inhalers with a spacer has been demonstrated as effective as the nebulized drug in managing acute exacerbations of asthma.