Decreased pulmonary artery pressure by oral sildenafil ingestion at mild altitude and during exercise in air pollution increases exercise performance

Project Title: Decreased pulmonary artery pressure by oral sildenafil ingestion at mild altitude and during exercise in air pollution increases exercise performance

Researchers: K.W. Rundell, W. Dempsey, K. Uhranowsky (Marywood University, Scranton, Pennsylvania, USA), W. Rowland (Tufts University School of Medicine, Massachusetts, USA)

Year accepted: 2007

Summary: The aims of this project are to determine if a therapeutic dose of sildenafil enhances exercise performance and aerobic capacity 1) in high PM pollution and 2) at mild simulated altitude consistent with Olympic venue altitudes, 3) elucidate a potential mechanism, and 4) confirm measurement of sildenafil and metabolites in plasma and urine. These studies will provide evidence detailing performance enhancement from prior-to-competition ingestion of oral sildenafil at 1) high air pollution venues and at 2) mild altitude.